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A nighttime routine with Xyzal®
Help your patients say good night to uncontrolled symptoms and good morning to a productive day ahead.
An allergy routine that benefits your patients
*Compared to placebo.1,2
What do we mean by nighttime routine?
Adding Xyzal® tackles your patient’s symptoms head on for over 24 hours.
Why recommend a nighttime routine with Xyzal®?
Over 60% of patients report impaired sleep.4 Due to interrupted sleep and uncontrolled symptoms:
Waking up to unmanaged symptoms starts your patient's day off on a negative note and can have a domino effect on their entire day.
Allergists recommended Xyzal® over two leading allergy brands, Claritin® and Benadryl®, combined.6
Xyzal® controls indoor and outdoor allergy symptoms
Xyzal® is an oral, OTC antihistamine that tackles allergy symptoms head on for over 24 hours, providing a restful nights sleep for a productive next day.
Relieves sneezing, runny nose, itchy nose or throat, and itchy, watery eyes
>24 hour efficacy7
Starts working effectively in 45 minutes8
Improves quality of life*1,2
Minor sedative effect9
*Compared to placebo1,2
How does Xyzal® compare?*
Xyzal® is lower price per dose compared to the leading allergy brands
vs. Claritin®:
Starts working at least 30 minutes faster than Claritin®**8
Superior to Claritin® at relieving seasonal allergic rhinitis symptoms8
vs. Zyrtec®:
In a controlled clinical trial, patients feel more satisfied with Xyzal® than Zyrtec®10
Approximately half the size of Zyrtec®, meaning patients are exposed to less medication per dose†
vs. Benadryl®:
Lasts up to 6x longer than Benadryl®‡11
Has a lower sedative effect than Benadryl®9
*To other branded OTC oral antihistamines.
** In two placebo-controlled, randomized studies comparing efficacy directly in patients with SAR, Xyzal® had an onset of action of just 45 minutes vs. 75 minutes with Claritin®, and in patients with PAR, Xyzal® had an onset of action of 1 hour vs. 90 minutes with Claritin®. Applies to first dose only.8
†Xyzal® 5 mg per dose vs. Zyrtec® 10 mg per dose.
‡Based on label dosing.11
§Compared to average retail prices of leading oral allergy brands, L52W ending 12/29/24.
OTC, over the counter, PAR, perennial allergic rhinitis; SAR, seasonal allergic rhinitis
Explore Xyzal® efficacy in more detail
Proven allergy relief for up to 29 hours*7
29 hours after the intake of one dose, the mean difference in Major Symptom Complex (MSC) score between Xyzal® and placebo was -3.80 (95% CI [-5.38; -2.22]).
- The MSC consists of 6 individual symptoms – runny nose, itchy nose, sniffles, nose blows, sneezes, and watery eyes
A nighttime routine with Xyzal® significantly improves quality of life**2
Xyzal® significantly improved all health related quality of life (HRQOL) categories compared to placebo (P<0.001).
Compared to placebo, Xyzal® had a relative improvement of:
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37.4% in emotional function score
40.8% in sleep score
38.5% in activity limitation scores
Xyzal® maintains efficacy long term*1
Xyzal® achieved a statistically significant improvement from baseline of mean Total 5 Symptom Score (T5SS) of 1.14
(P<001) compared to placebo over a 4 week treatment period.
- The improvement in T5SS was maintained for the entire 6 month study period
Xyzal® has little or no impact on attention or performance12,13
- Multiple studies have confirmed that Xyzal® is well- tolerated, and has little or no impact on memory, attention or performance the next day12,13
- Xyzal® has a minor effect on sedative properties, such as drowsiness and impaired performance9
- The adverse event profile in adults and adolescents is similar in short-term and long-term studies14
*A double-blind placebo and active-controlled environmental exposure unit study in patients with SAR compared MSC scores between Xyzal® 5 mg vs Zyrtec® 10 mg vs placebo.7
**A double-blind, randomized study comparing the impact on health-related quality of life (HRQOL), efficacy and safety of Xyzal® 5 mg (n=278) versus placebo (n=273) administered once daily over a 6–month period in persistent allergic rhinitis.2
†Across 8 placebo-controlled short term studies (1–6 weeks in duration) in adult patients (12 years of age and older)14
‡In 2 placebo-controlled studies in pediatric patients (6–12 years of age)14
CI, confidence interval; HRQOL, health related quality of life; MSC, major symptom complex; SAR, seasonal allergic rhinitis; T5SS, total 5 symptom score.
Explore how Xyzal® compares in more detail
Xyzal® starts working 30 minutes faster than Claritin®*8
In patients with seasonal allergic rhinitis (SAR) (n=68):
- Treatment effect of Xyzal® was observed at 45 min (P=0.050 vs placebo) after medication intake, compared with 1 h 15 min (p<0.001 vs placebo) for Claritin®
In patients with perennial allergic rhinitis (PAR) (n=35):
- Treatment effect of Xyzal® was observed at 1 hour (P<0.005 vs placebo) after medication intake compared with 1 h 30 min (p=0.043 vs placebo) for Claritin®
Patients feel more satisfied with Xyzal® than Zyrtec®**15
Xyzal® improved mean visual analog scale (VAS) by 5.00 (95% CI [0.28; 9.71], P=0.038) compared to Zyrtec®.
- During the first 4.5 hours after treatment, mean VAS (SD) was 70.2 (23.6) and 65.2 (26.4) in Xyzal® and Zyrtec® respectively, and 41.2 (31.3) in the placebo group
*Two placebo-controlled, randomized studies comparing efficacy directly in patients with seasonal allergic rhinitis (SAR) or perennial allergic rhinitis (PAR) using an environmental exposure unit (the Vienna Challenge Chamber) found Xyzal® to have faster onset of action than Claritin® in both SAR and PAR.
Applies to first dose only.8
**A placebo-controlled, randomized, head-to-head exploratory clinical trial conducted in Environment Exposure Unit compared MSC scores between Xyzal® 5 mg vs. Zyrtec® 10 mg vs. placebo.15
MSC, major symptom complex; PAR, perennial allergic rhinitis; SAR, seasonal allergic rhinitis; SD, standard deviation; VAS, visual analog scale.
Our products
Xyzal® Allergy 24HR
To be taken at night for over 24-hours of sustained symptom control, providing relief through the night and entire next day. For adults and children 6 years of age and older.
- Ask a doctor
- Take 1 tablet (5 mg) once daily in the evening
- Do not take more than 1 tablet (5 mg) in 24 hours
- 1⁄2 tablet (2.5 mg) once daily in the evening may be appropriate for less severe symptoms
- Take 1⁄2 tablet (2.5 mg) once daily in the evening
- Do not take more than 1⁄2 tablet (2.5 mg) in 24 hours
- Do not use
- Do not use
- If you have kidney disease
- If you have ever had an allergic reaction to this product or any of its ingredients or to an antihistamine containing cetirizine
- Ever had trouble urinating or emptying your bladder
- Drowsiness may occur
- Avoid alcoholic drinks
- Alcohol, sedatives, and tranquilizers may increase drowsiness
- Be careful when driving a motor vehicle or operating machinery
- You have trouble urinating or emptying your bladder
- An allergic reaction to this product occurs. Seek medical help right away
- If breast-feeding: not recommended
- If pregnant: ask a health professional before use
- In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222).
- Store between 20° and 25° C (68° and 77° F)
- Safety sealed blister pack: do not use if carton was opened or if individual blister unit is open or torn
- Safety sealed bottle: do not use if carton was opened or if printed foil inner seal on bottle is torn or missing
Xyzal® Allergy 24HR temporarily relieves allergy symptoms including sneezing, itchy, watery eyes, runny nose, and itchy nose or throat.
Sizes: 10-count tablets | 20-count tablets | 35-count tablets | 55-count tablets | 80-count tablets | 110-count tablets
Active:
Levocetirizine dihydrochloride 5 mg (Antihistamine)
All ingredients:
Active ingredient: Levocetirizine dihydrochloride.
Inactive ingredients: colloidal anhydrous silica, hypromellose, lactose
monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol
400, titanium dioxide
Adults 65 years of age and older:
Adults and children 12-64 years of age:
Children 6-11 years of age:
Children under 6 years of age:
Consumers with kidney disease:
Use as directed.
Do not use
Ask a doctor before use if you have
When using this product
Stop use and ask a doctor if
If pregnant or breast-feeding
Keep out of reach of children.
Children's Xyzal® Allergy 24HRAllergy 24HR
Liquid formulation in grape and bubble gum flavors to be taken before bedtime for over 24-hours of continuous relief through the night and entire next day. For children 2 years of age and older.
- Ask a doctor
- Take 5 mL or 10 mL once daily in the evening depending upon severity of symptoms
- Do not take more than 10 mL in 24 hours
- Take 5 mL once daily in the evening
- Do not take more than 5 mL in 24 hours
- Take 2.5 mL once daily in the evening
- Do not take more than 2.5 mL in 24 hours
- Do not use
- Do not use
- If you have kidney disease
- If you have ever had an allergic reaction to this product or any of its ingredients or to an antihistamine containing cetirizine
- Ever had trouble urinating or emptying your bladder
- Drowsiness may occur
- Avoid alcoholic drinks
- Alcohol, sedatives, and tranquilizers may increase drowsiness
- Be careful when driving a motor vehicle or operating machinery
- You have trouble urinating or emptying your bladder
- An allergic reaction to this product occurs. Seek medical help right away
- If breast-feeding: not recommended
- If pregnant: ask a health professional before use
- In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222).
- Store between 20° and 25° C (68° and 77° F)
- Safety sealed bottle: do not use if carton was opened or if printed foil inner seal on bottle is torn or missing
Children's Xyzal® Allergy 24HR temporarily relieves allergy symptoms including sneezing,
itchy, watery eyes, runny nose, and itchy nose or throat.
Active:
Levocetirizine dihydrochloride 5 mg (Antihistamine)
All ingredients:
Active ingredient: Levocetirizine dihydrochloride.
Inactive ingredients: flavor, glacial acetic acid, glycerin, maltitol solution, methylparaben, propylparaben, purified water, saccharin sodium, sodium acetate trihydrate
Adults 65 years of age and older:
Adults and children 12-64 years of age:
Children 6-11 years of age:
Children under 6 years of age:
Children under 2 years of age:
Consumers with kidney disease:
Use as directed.
Note: mL = milliliters
Do not use
Ask a doctor before use if you have
When using this product
Stop use and ask a doctor if
If pregnant or breast-feeding
Keep out of reach of children.
FAQs
Xyzal® tablets are suitable for patients aged 6 years and older who experience hay fever or other respiratory allergy symptoms. Liquid Xyzal® is suitable for children 2 years and above.
Drowsiness may occur. In clinical studies where Xyzal® was administered at night, 6% of users experienced drowsiness. Xyzal® should be taken at night, and users should be careful if driving a motor vehicle or operating machinery.
Xyzal® starts to work in less than one hour. Check out Explore how Xyzal® compares in more detail to learn more.
Prices vary depending on retailer.
Patients can get exclusive savings by signing up here.
Xyzal® may interact with alcohol, other medicines that can cause drowsiness (cold or allergy medicines, sedatives, narcotics, sleeping pills, muscle relaxers, medicine for seizures, depression or anxiety), ritonavir, or theophylline.16
Click here to order samples.
Across efficacy, onset of action, and size, Xyzal® stands out compared to some other available OTC oral antihistamines. See How does Xyzal® compare for more information.
Xyzal® relieves allergy symptoms including sneezing, runny nose, itchy nose or throat, and itchy, watery eyes.
No, Xyzal® does not need to be taken with food.
Contact us
Submit your question online or call 1-800-633-1610 (M-F 8 a.m.-6 p.m. ET)
1. Bachert C, et al. J Allergy Clin Immunol. 2004;114(4):838–844. 2. Walter Canonica G, et al. Respir Med. 2006;100(10):1706–1715. 3. Huston Methodist. Allergy Symptoms Keeping You Up at Night? Try These Tips. Accessed 01/2025. https://www.houstonmethodist.org/blog/articles/2024/jun/allergy-symptoms-keeping-you-up-at-night-try-these-tips//. 4. Baena-Cagnani CE, et al. World Allergy Organ J. 2015;8(Suppl 1):A239. 5. Schoenwetter WF, et al. Curr Med Res Opin. 2004;20(3):305–317. 6. Data on file. Based on 2024 IQVIA ProVoice Survey regarding allergist most recommended adult oral antihistamine brand. 7. FDA clinical review. NDA 209-089 and NDA 209-090. 8. Stübner P, et al. Curr Med Res Opin. 2004;20(6):891–902. 9. Kawauchi H, et al. Int J Mol Sci. 2019;20(1):213. 10. Data on file. Based on a head-to-head comparison clinical trial between a single dose of levocetirizine 5 mg tablets and cetirizine 10 mg tablets in Environmental Exposure Unit. 11. Benadryl- diphenhydramine hydrochloride tablet. (2024). 12. Verster JC, et al. J Allergy Clin Immunol. 2003;111(3):623–627. 13. Gandon JM, Allain H. Br J Clin Pharmacol. 2002;54(1):51–58. 14. FDA Medical Review. NDA 22-064. 15. Data on file. More patients were satisfied with levocetirizine than cetirizine in a head-to-head comparison clinical trial conducted in Environment Exposure Unit. 16. RxList. Xyzal (levocetirizine dihydrochloride) drug. Accessed 01/2025. https://www.rxlist.com/xyzal-drug.htm.